| 摘要: |
| ［摘要］ 目的 探讨支气管肺泡灌洗液（BALF）G试验和GM试验对侵袭性曲霉菌感染的早期诊断价值。方法 检测32例侵袭性肺部曲霉菌感染患者和24例肺部细菌性感染患者的BALF的GM抗原和BG抗原水平。计算G试验和GM试验的灵敏度、特异度、阳性预测值和阴性预测值。使用ROC曲线比较G试验和GM试验的诊断价值，用kappa值来说明G试验和GM试验诊断的一致性。结果 G试验的灵敏度、特异度、阳性预测值和阴性预测值分别为84.38%、83.33%、87.10%和80.00%，曲霉菌感染患者BALF的BG浓度明显高于细菌性感染患者(P<0.05)。GM试验的灵敏度、特异度、阳性预测值和阴性预测值分别为81.25%、87.50%、89.66%和77.78%，曲霉菌感染患者BALF的I值明显高于细菌性感染患者(P<0.05)。G试验和GM试验ROC曲线下面积分别为0.839和0.844，kappa值为0.57，一致性较好，差异无统计学意义(P>0.05)。G试验的灵敏度略高于GM试验，而GM试验的特异度则高于G试验，差异均无统计学意义(P>0.05)。结论 BALF G试验和GM试验对侵袭性曲霉菌的早期临床诊断有重要意义,诊断结果具有较好的一致性。 |
| 关键词: 半乳甘露聚糖 (1,3)-β-D葡聚糖 侵袭性曲霉菌病 支气管肺泡灌洗液 |
| DOI：10.3969/j.issn.1674-3806.2015.07.08 |
| 分类号:R 379 |
| 基金项目: |
|
| The diagnostic value of bronchoalveolar lavage fluid galactomannan antigen assay and 1, 3 beta-D-glucan assay for invasive aspergillosis |
|
CHEN Hui-peng, ZHONG Ru-zhu, LI Li
|
|
Department of Respiratory Medicine, Lianjiang People′s Hospital, Guangdong 524000, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the value of galactomannan antigen assay and 1, 3 beta-D-glucan assay in bronchoalveolar lavage fluid(BALF) in the early diagnosis for invasive aspergillosis.Methods A total of 32 patients with invasive aspergillosis and 24 patients with bacterial infections were performed G test and GM test and the levels of BG antigen and GM antigen were measured. The sensitivity, specificity, positive predictive values and negative predictive value were calculated. The ROC curve was used to compare the diagnostic values of G test and GM test, with kappa values to illustrate the consistency of G test and GM test.Results The sensitivity, specificity, positive predictive values and negative predictive value were 84.38%, 83.33%, 87.10% and 80.00% respectively in G test, and 81.25%, 87.50%, 89.66% and 77.78% respectively in GM test. The levels of BG antigen and GM antigen in patients with invasive aspergillosis were significantly higher than those in patients with bacterial infection(P<0.05). The areas under the ROC curve were respectively 0.839 and 0.844 in G test and GM test, with kappa value 0.57(P>0.05). The sensitivity of G test was slightly higher than that of GM test, while the specificity of the G test was slightly lower than that of GM test, without a significant difference(P>0.05).Conclusion BALF G test and GM test is very important for early diagnosis of invasive aspergillosis. |
| Key words: Galactomannan (1,3)-β-D-glucan Invasive aspergillosis Bronchoalveolar lavage fluid |
