| 摘要: |
| ［摘要］ 目的 探讨心衰患者ACE及CYP2D6遗传多态性与培哚普利疗效的关联性。方法 选取158例心衰患者，应用PCR方法检测其ACE及CYP2D6多态性，给予培哚普利治疗，对治疗前后的左室舒张末期内径(LVDD)、左室射血分数(LVEF)和血浆血管紧张素Ⅱ(AngⅡ)进行检测。结果 DD/CC、DD/CT和DD/TT型患者经治疗后，LVDD明显缩小，且血浆AngⅡ水平下降的幅度最大。结论 ACE基因的多态性与培哚普利的治疗效果有关联性，CYP2D6基因多态性对培哚普利的疗效无明显影响。 |
| 关键词: ACE基因多态性 培哚普利 |
| DOI：10.3969/j.issn.1674-3806.2015.08.12 |
| 分类号:R 541.6 |
| 基金项目: |
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| The correlation between ACE and CYP2D6 polymorphism and the effect of perindopril |
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PENG Jun,HUANG Zi-ming,GUO Guan-hua
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Department of Cardiology, Zhanjiang Central People′s Hospital, Guangdong 524000,China
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| Abstract: |
| ［Abstract］ Objective To investigate the correlation between ACE and CYP2D6 polymorphism and the effect of perindopril.Methods The genotype was determined by PCR in 158 patients. The differences of left ventricular end-diastolic diameters(LVDD), left ventricular ejection fractions(LVEF) and AngⅡlevel before and after perindopril treatment were detected.Results The patients with DD/CC, DD/CT and DD/TT phenotype had a great decrease in LVDD and AngⅡ after perindopril treatment.Conclusion ACE polymorphisms correlates to the effect of perindopril treatment. CYPD2D6 polymorphism does not correlate to the perindopril treatment. |
| Key words: ACE polymorphisms Perindopril |
