| 摘要: |
| ［摘要］ 目的 比较不同剂量乙肝免疫球蛋白（HBIG）联合乙肝疫苗阻断乙肝病毒母婴传播的疗效。方法 将HBsAg阳性孕妇分娩的新生儿124例分为双阳组60例和单阳组64例。双阳组按家长的意愿分为双阳大剂量组30例和双阳小剂量组30例，单阳组亦分为单阳大剂量组和单阳小剂量组各32例。新生儿出生后6 h内，大剂量组予肌注HBIG 200 U，小剂量组予肌注HBIG 100 U；同时联合应用乙肝疫苗。一周岁时检测HBV血清学标志物（乙肝五项）。结果 在双阳组中大剂量和小剂量HBIG的乙肝母婴阻断率分别为93.3%和83.3%；在单阳组中大剂量和小剂量HBIG的乙肝母婴阻断率分别为100.0%和96.9%,差异无统计学意义（P>0.05）。结论 孕妇HBsAg阳性时，新生儿出生后要及时注射HBIG，用量100 U或200 U均可。 |
| 关键词: 乙肝免疫球蛋白 乙型肝炎病毒 母婴传播 |
| DOI：10.3969/j.issn.1674-3806.2015.08.16 |
| 分类号:R 512.6+2 |
| 基金项目: |
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| Comparison of different doses of hepatitis B immune globulin in blocking infection of hepatitis B virus by mother-to-fetus transmission for newborns |
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XIE Ruo-xin, YANG Jie-fang, HUO Le-ying
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Department of Child Care, Zhuhai Maternity and Child Health Hospital, Guangdong 519000, China
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| Abstract: |
| ［Abstract］ Objective To explore the efficacy of different doses of hepatitis B immune globulin in blocking infection of hepatitis B virus by mother-to-fetus transmission for newborns.Methods 124 newborns who were born by HBsAg-positive mothers in our hospital were divided into single positive group(n=60) and double positive group(n=64). The patients in the double positive group were randomly divided into a small dose double positive subgroup(n=30) and a big dose double positive subgroup(n=30), and the patients in the single positive group were randomly divided into a small dose double positive subgroup(n=32) and a big dose double positive subgroup(n=32). The big dose groups were intramuscularly injected with HBIG 200 U and the small dose groups were intramuscularly injected with HBIG 100 U, with all groups in combination of hepatitis B vaccine within 6 hours after childbirth. HBV serological markers(HB 5 tests)were detected at the age of one.Results There were no significant differences in blocking rate of vertical transmission of hepatitis B between the large dose(200 U) and the small dose(100 U) of HBIG in both double positive group and single positive group.Conclusion Newborns of HBsAg-positive mothers should be injected with HBIG in time either in dose of 100 U or 200 U. |
| Key words: Hepatitis B immune globulin Hepatitis B virus Vertical transmission |
