| 摘要: |
| ［摘要］ MicroRNA（miRNA）是一类调节基因，是内源性非编码、长度为18～22个核苷酸的小分子RNA，在转录后水平调节基因表达发挥重要的生物学作用。近期研究表明，miRNA表达水平的变化与心律失常密切相关，诸如miR-1、miR-133、miR-328、miR-208、miR-21及miR-15等可通过细胞膜离子通道的功能和异常表达引发心律失常，干预和调控miRNA的表达水平，有望为心律失常的诊疗提供一个新靶点。 |
| 关键词: MicroRNA 心律失常 离子通道 调控 |
| DOI：10.3969/j.issn.1674-3806.2015.08.32 |
| 分类号:R 561.7 |
| 基金项目: |
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| New research progress of microRNA and its cause of related-arrhythmia |
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ZENG Xian- you, TAN Yi
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Department of Internal Medicine, the People′s Hospital of Hanshou County, Hunan 415900, China
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| Abstract: |
| ［Abstract］ MicroRNA(miRNA) is a kind of regulatory gene with an endogeous small non-coding RNA of 18～22 nucleotides in length and plays an important role in biological process, which participates in regulating expression at post-transcriptional level. Current studies indicate that changes of miRNA expression levels are closely related to the formation of arrhythmia, for example, miR-1, miR-133, miR-328, miR-208, miR-21 and miR-15 can lead to arrhythmia through dysfunctions and abnormal expressions in cell membrane ion channels. Intervene and regulation expression levels of miRNAs may become a novel diagnosis therapeutic target for arrhythmia. |
| Key words: MicroRNA Arrhythmia Ion channel Regulation |
