| 摘要: |
| ［摘要］ 辐射抵抗的三个主要机制为内在辐射敏感性、肿瘤细胞增殖和乏氧。磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（AKT）信号通路是肿瘤细胞的存活通路之一，该通路的激活与辐射抵抗密切相关。该文就PI3K/AKT信号通路与辐射抵抗机制作一综述。 |
| 关键词: 放射治疗 磷脂酰肌醇3激酶 蛋白激酶B 辐射抵抗 |
| DOI：10.3969/j.issn.1674-3806.2015.08.33 |
| 分类号:R 73.33；R 815 |
| 基金项目:广西科学研究与技术开发计划项目（编号：桂科攻1140003B-69）；广西自然科学基金资助项目（编号：2010GXNSFB013081） |
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| The PI3-K/AKT signaling pathway and radiation resistance mechanisms |
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QIN Jian, LU He-ming, CHEN Jia-xin
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Department of Radiation Oncology of Clinical Cancer Center, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ The three major radiation resistance mechanisms are intrinsic radiosensitivity, tumor cell proliferation and hypoxia. The phosphatidy-linositol-3-kinase(PI3-K)/protein kinase B(AKT) pathway is one of the survival pathways of tumor cells. Activation of this pathway is closely related to radiation resistance. This review focuses on the PI3K/AKT signal pathway and radiation resistance mechanisms. |
| Key words: Radiotherapy Phosphatidy-linositol-3-kinase(PI3-K) Protein kinase B(AKT) Radiation resistance |
