| 摘要: |
| ［摘要］ 目的 探讨附子临床应用中出现不良反应的影响因素。方法 选取2013-01～2014-08该院收治的确诊为寒湿痹阻型痹证采用中医复方治疗的患者240例为研究对象，根据复方有无附子分为A组和B组各120例，A组给予未加附子复方治疗，B组给予附子复方治疗，观察两组的临床不良反应情况。结果 A组发生不良反应16例（13.33%），B组发生不良反应60例（50.00%），两组差异有统计学意义（χ2=32.28，P=0.000）。B组120例患者中，有不良反应组先煎时间与煎煮总时间（min）均明显短于无不良反应组［（36.5±4.23） vs （31.46±3.16），P=0.000；（89.75±1.52） vs （86.36±2.42），P=0.000］；平均使用剂量(g)也明显高于无不良反应组［（24.15±6.26） vs （20.53±3.52），t=16.712,P=0.017］。结论 附子的先煎时间、煎煮总时间及其使用剂量均是影响其临床不良反应的因素。 |
| 关键词: 附子 煎煮时间 使用剂量 不良反应 |
| DOI：10.3969/j.issn.1674-3806.2015.09.21 |
| 分类号:R 282 |
| 基金项目: |
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| The relations between adverse reactions of aconite root compound and its decoction time as well as dosage |
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LIANG Bi-yan, ZHONG Wei-xiang, LI Shang, et al.
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Department of Pharmacy, Guangdong Inductrial Injury Rehabilitation Hospital, Guangzhou 510000, China
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| Abstract: |
| ［Abstract］ Objective To explore the influence factors of adverse reactions on the clinical application of aconite root.Methods 240 patients who received the therapy of traditional Chinese medicine(TCM) were selected as the research objects and were randomly divided into two groups. Group A was given the treatment of TCM compounds without aconite root(n=120), while group B was given the matched prescriptions with aconite root(n=120). The clinical adverse reactions were compared between the two groups.Results There were 16 cases(13.33%) with adverse reactions in group A, and 60 cases(50.00%) in group B, with a significant difference（χ2=32.28, P=0.000）. Among 120 patients of group B, the first decoction time and the total decoction time were significantly shorter in the subgroup of adverse reactions than those in the subgroup of non-adverse reactions［（36.5±4.23） min vs （31.46±3.16）min, P=0.000; （89.75±1.52）min vs （86.36±2.42）min, P=0.000］. The mean dose of the subgroup of adverse reactions was significantly higher than that of the subgroup of non-adverse reactions［（24.15±6.26） vs （20.53±3.52）, t=16.712, P=0.017］.Conclusion Decoction time of aconite root and its dosage are the factors that affect the clinical adverse reactions. |
| Key words: Aconite Decoction time Dose Adverse reactions |
