| 摘要: |
| ［摘要］ 目的 探讨功能性消化不良（FD）患者外周血浆神经肽S受体-1（NPSR1）、降钙素基因相关肽（CGRP）、白介素6（IL-6）的水平变化与精神心理因素的关系。方法 选取136例FD患者，其中餐后不适综合征（PDS）组77例，上腹痛综合征（EPS）组59例，以同期40名健康人作为对照组，采用抑郁自评量表（SDS）、焦虑自评量表（SAS）对FD患者的焦虑、抑郁情况进行评估，采用ELISA法检测血浆中NPSR1、IL-6、CGRP的浓度，分析FD不同亚型NPSR1、IL-6、CGRP及其与焦虑、抑郁之间的相关性。结果 PDS组、EPS组的焦虑、抑郁评分均高于对照组（P<0.01），PDS组焦虑评分高于EPS组（P<0.01）。PDS组中，SAS评分与SDS评分呈正相关（P<0.05）。FD组中，NPSR1水平与焦虑评分呈负相关（P<0.01）；PDS组中，NPSR1水平与焦虑评分呈负相关（P<0.05）。结论 FD患者存在明显焦虑、抑郁，精神心理因素与FD的发生密切相关，在PDS组患者中更明显，焦虑、抑郁对FD的发生起促进作用，它在FD不同亚型的发病中所起的作用存在差异。NPSR1参与调节FD患者的焦虑情绪，PDS组患者的焦虑情绪影响NPSR1的分泌，对焦虑或抑郁的FD患者进行药物治疗及心理治疗等综合治疗措施，能提高疗效，改善患者的生活质量。 |
| 关键词: 消化不良 白介素6 降钙素基因相关肽 神经肽S受体-1 精神心理因素 |
| DOI：10.3969/j.issn.1674-3806.2017.02.09 |
| 分类号:R 57 |
| 基金项目: |
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| The relationship between psychological factors and the levels of NPSR1, CGRP and IL-6 in patients with peripheral blood plasma of functional dyspepsia |
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HUANG Geng-zhen, HE Guo-bin, ZHOU Xiao-qing, et al.
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Department of Gastroenterology, Nanchong Central Hospital, Sichuan 637000, China
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| Abstract: |
| ［Abstract］ Objective To explore the relationship between psychological factors and the levels of NPSR1, CGRP and IL-6 in patients with peripheral blood plasma of functional dyspepsia(FD).Methods One hundred and thirty-six FD patients were divided into PDS group(n=77) and EPS group(n=59). During the same period of the treatment 40 healthy people without FD and other disease were collected as the control group. The related data were recorded by using Self-Rating Depression Scale(SDS) and Self-Rating Anxiety Scale(SAS). The anxious and depressive symptoms were compared among the PDS, EPS and the control group. The anxious and depressive symptoms were compared between the PDS and EPS groups. The levels of NPSR1, IL-6 and CGRP were detected using ELISA. The relationship between the levels of NPSR1, IL-6 and CGRP and the patients′ anxious and depressive symptoms was analyzed.Results The scores of anxiety in the PDS group and the EPS group were higher significantly than the those in the control group(P<0.01). The scores of anxiety in the PDS group were significantly higher than those in the EPS group(P<0.01). In the PDS group, the scores of SAS were positively related to the scores of SDS(P<0.05). In the FD group, the level NPSR1 was negatively related to the scores of anxiety(P<0.01). In the PDS group, the level of NPSR1 was negatively related to the scores of anxiety(P<0.05).Conclusion The psychological factors are positively related to the occurrence of FD. NPSR1 plays an important role in the regulation of anxiety in FD patients. |
| Key words: Dyspepsia Interleukin-6 Calcitoningene-related peptide Neural peptide S receptor 1 Psychological Factors |
