| 摘要: |
| ［摘要］ 目的 研究幽门螺杆菌（Hp）感染对冠心病患者抗血小板治疗效果及远期预后的影响。方法 选取该院2012-05～2015-05收治的97例冠心病患者为研究对象，所有患者接受抗血小板治疗，根据Hp感染情况将患者分为感染组（n=62）与未感染组（n=35）。分析两组抗血小板效果、血脂水平以及1年内预后。结果 感染组治疗后的纤维蛋白原、总胆固醇、消化道出血率、心血管事件发生率分别为（5.21±1.57）g/L、（5.36±1.17）mmol/L、21.0%、29.0%，显著高于未感染组的（3.32±1.19）g/L、（4.24±1.35）mmol/L、5.7%、11.4%（P<0.05）。结论 幽门螺杆菌感染可能对冠心病抗血小板治疗效果产生影响，诱发心血管事件，增加消化道出血风险，不利于患者的远期预后。 |
| 关键词: 冠心病 抗血小板治疗 幽门螺杆菌 |
| DOI：10.3969/j.issn.1674-3806.2017.12.25 |
| 分类号:R 54 |
| 基金项目: |
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| Effect of Hp infection on anti-platelet therapy and long-term prognosis in patients with coronary heart disease |
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ZHANG Shi-ming
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The First Department of Internal Medicine, Dengta Hospital of Anyang City, Henan 455000, China
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| Abstract: |
| ［Abstract］ Objective To study the effect of Hp infection on anti-platelet therapy and long-term prognosis in patients with coronary heart disease(CHD).Methods From May 2012 to May 2015, 97 patients with CHD in our hospital were given anti-platelet therapy and they were divided into the infection group(n=62) and the non-infection group(n=35). The effects of anti-platelet therapy, the levels of blood lipid and the prognosis were analyzed within 1 year of the therapy.Results After the treatment, the levels of fibrinogen and total cholesterol, the incidence rates of digestive tract hemorrhage and cardiovascular events in the infection group［(5.21±1.57)g/L, (5.36±1.17)mmol/L,21.0%, 29.0%］ were significantly higher than those in the non-infection group［(3.32±1.19)g/L, (4.24±1.35)mmol/L, 5.7%, 11.4%］(P<0.05).Conclusion Helicobacter pylori infection may have adverse effects on the anti-platelet therapy in the patients with CHD, which induce cardiovascular events and increase the risk of gastrointestinal bleeding and which is unfavorable for the long-term prognosis. |
| Key words: Coronary heart disease(CHD) Anti-platelet therapy Helicobacter pylori |
