引用本文:张士铭.Hp感染对冠心病患者抗血小板治疗效果及远期预后的影响[J].中国临床新医学,2017,10(12):1207-1210.
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Hp感染对冠心病患者抗血小板治疗效果及远期预后的影响
张士铭
455000 河南, 安阳市灯塔医院内一科
摘要:
[摘要] 目的 研究幽门螺杆菌(Hp)感染对冠心病患者抗血小板治疗效果及远期预后的影响。方法 选取该院2012-05~2015-05收治的97例冠心病患者为研究对象,所有患者接受抗血小板治疗,根据Hp感染情况将患者分为感染组(n=62)与未感染组(n=35)。分析两组抗血小板效果、血脂水平以及1年内预后。结果 感染组治疗后的纤维蛋白原、总胆固醇、消化道出血率、心血管事件发生率分别为(5.21±1.57)g/L、(5.36±1.17)mmol/L、21.0%、29.0%,显著高于未感染组的(3.32±1.19)g/L、(4.24±1.35)mmol/L、5.7%、11.4%(P<0.05)。结论 幽门螺杆菌感染可能对冠心病抗血小板治疗效果产生影响,诱发心血管事件,增加消化道出血风险,不利于患者的远期预后。
关键词:  冠心病  抗血小板治疗  幽门螺杆菌
DOI:10.3969/j.issn.1674-3806.2017.12.25
分类号:R 54
基金项目:
Effect of Hp infection on anti-platelet therapy and long-term prognosis in patients with coronary heart disease
ZHANG Shi-ming
The First Department of Internal Medicine, Dengta Hospital of Anyang City, Henan 455000, China
Abstract:
[Abstract] Objective To study the effect of Hp infection on anti-platelet therapy and long-term prognosis in patients with coronary heart disease(CHD).Methods From May 2012 to May 2015, 97 patients with CHD in our hospital were given anti-platelet therapy and they were divided into the infection group(n=62) and the non-infection group(n=35). The effects of anti-platelet therapy, the levels of blood lipid and the prognosis were analyzed within 1 year of the therapy.Results After the treatment, the levels of fibrinogen and total cholesterol, the incidence rates of digestive tract hemorrhage and cardiovascular events in the infection group[(5.21±1.57)g/L, (5.36±1.17)mmol/L,21.0%, 29.0%] were significantly higher than those in the non-infection group[(3.32±1.19)g/L, (4.24±1.35)mmol/L, 5.7%, 11.4%](P<0.05).Conclusion Helicobacter pylori infection may have adverse effects on the anti-platelet therapy in the patients with CHD, which induce cardiovascular events and increase the risk of gastrointestinal bleeding and which is unfavorable for the long-term prognosis.
Key words:  Coronary heart disease(CHD)  Anti-platelet therapy  Helicobacter pylori