| 摘要: |
| ［摘要］ 结核病是全球面临的重大公共卫生问题，结核病患者的早期快速检测对提高患者的疗效，并有效阻断结核人际传播至关重要。结核病诊断能力不足是导致发现率和报告率较低的根本原因，尤其在患者面对交通、经济负担等一系列问题时，进一步加剧患者的漏诊。然而传统的结核分枝杆菌实验室检测方法已无法满足临床的实际需求，亟待在结核病高负担国家使用和推广新型诊断技术，近年来随着免疫学、分子生物学、质谱等新兴技术发展，涌现出一批结核病快速检测产品。该文对不同类型的结核分枝杆菌实验室检测产品和技术进行回顾和分析。 |
| 关键词: 分枝杆菌 结核 实验室 进展 |
| DOI：10.3969/j.issn.1674-3806.2021.01.05 |
| 分类号:R 378.91+1 |
| 基金项目:国家自然科学基金项目（编号：82072243） |
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| Advances in laboratory products and techniques for detection of Mycobacterium tuberculosis |
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PANG Yu, WANG Yu-feng, GAO Xing-hui, et al.
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Department of Bacteriology & Immunology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
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| Abstract: |
| ［Abstract］ Tuberculosis is a major public health problem facing the world. Early and rapid detection of Mycobacterium tuberculosis is crucial to improving the treatment effect of tuberculosis patients and can effectively interrupt the transmission of tuberculosis from person to person. Lack of diagnostic capacity for tuberculosis is the root cause leading to the lower discovering and reporting rates of the disease, especially when the patients are faced with a series of problems such as transportation and economic burden, which further aggravates the missed diagnosis of the patients. However, the traditional laboratory detection methods for Mycobacterium tuberculosis can no longer meet the actual clinical needs. It is urgent to use and promote new diagnostic techniques in countries with high tuberculosis burden. In recent years, with the development of emerging technologies such as immunology, molecular biology and mass spectrometry, a number of rapid detection products of Mycobacterium tuberculosis have emerged. This paper reviews and analyzes different types of laboratory products and techniques for detection of Mycobacterium tuberculosis. |
| Key words: Mycobacterium Tuberculosis Laboratory Advances |
