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| Novel therapeutic avenues for therapy-resistant prostate cancer: a review |
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XU Ling-fan, William Butler, HUANG Jiao-ti
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Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA(XU Ling-fan, William Butler, HUANG Jiao-ti);Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei 230001, China(XU Ling-fan)
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| 摘要: |
| ［Abstract］ Although hormonal therapy is effective initially for metastatic prostate cancer(PCa), therapy resistance invariably occurs. Our team has been dedicated to investigating potential mechanisms and exploiting novel therapeutic managements for those advanced patients who have run out of treatment of choice for decades. Our study scopes mainly focus on tumor biomarker identification, neuroendocrine differentiation and tumor metabolism. This review summarizes some of our key findings to advance understandings of how PCa progresses and what potential treatment regimens are. |
| 关键词: Prostate cancer Therapeutic resistance Tumor biomarker Tumor metabolism |
| DOI：10.3969/j.issn.1674-3806.2021.07.02 |
| 分类号:R 737.25 |
| 基金项目:This study was financially supported by National Natural Science Foundation of China(86902611) |
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| 激素抵抗型前列腺癌的治疗新策略 |
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徐凌凡，William Butler，黄教悌
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27710 美国，杜克大学医学院病理系（徐凌凡，William Butler，黄教悌）；230001 合肥，安徽医科大学第一附属医院泌尿外科（徐凌凡）
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| Abstract: |
| ［摘要］ 转移性前列腺癌通过激素剥夺疗法大多可获得良好的治疗效果，然而肿瘤细胞最终产生激素抵抗，对治疗无应答。该研究团队长期致力于探索前列腺肿瘤的激素抵抗的产生机制并寻求新的治疗策略，研究范围主要集中在鉴定新的肿瘤标志物，神经内分泌分化以及肿瘤代谢等方面。该文将综述本课题组最新的几项研究成果，以期加深对前列腺癌进展机制的理解并提出新的治疗策略。 |
| Key words: 前列腺癌 激素抵抗 肿瘤标志物 肿瘤代谢 |
