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| Pathological diagnosis of T-follicular helper cell lymphoma |
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ZHAO Yue, Jenna McCracken, WANG En-di
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Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, China(ZHAO Yue);Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA(ZHAO Yue, Jenna McCracken, WANG En-di)
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| 摘要: |
| ［Abstract］ T-follicular helper cell lymphoma(T-FHCL) is a type of peripheral T-cell lymphoma. The understanding of T-FHCL has been evolving over the course of several decades, and it was classified into three subcategories by the World Health Organization in 2017. Because T-FHCL often has misleading histopathological manifestations and incompletely clarified pathogenesis, its diagnosis is challenging and usually requires a series of multifaceted evaluations, especially for angioimmunoblastic T-cell lymphoma(the most common of the three subcategories). Along with recent advances in the field of molecular biology, the genomic landscape of T-FHCL has been unraveled, and the mechanism underlying its lymphomagenesis, especially the development of its unique microenvironment, is now better understood. In this commentary, we not only summarize the pathological features, the updated diagnostic criteria, and classification of T-FHCL, but also discuss the latest advances in the molecular study of T-FHCL and its application in diagnosis and disease classification. |
| 关键词: T-follicular helper cell lymphoma Angioimmunoblastic T-cell lymphoma Follicular T-cell lymphoma Nodal peripheral T-cell lymphoma with T-follicular helper phenotype Peripheral T-cell lymphoma |
| DOI：10.3969/j.issn.1674-3806.2021.09.03 |
| 分类号:R 733 |
| 基金项目: |
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| 滤泡辅助性T细胞淋巴瘤的病理诊断 |
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赵 月，Jenna McCracken，王恩第
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110001 沈阳，中国医科大学附属第一医院病理科暨基础医学院病理教研室（赵 月）；27710 美国，杜克大学医学院病理系（赵 月，Jenna McCracken，王恩第）
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| Abstract: |
| ［摘要］ 滤泡辅助性T细胞淋巴瘤(T-FHCL)是一种外周T细胞淋巴瘤，对它的认识几十年来一直在不断发展，世界卫生组织2017年分类将其分为三个亚类别。由于T-FHCL常有误导性的组织病理表现和未完全阐明的发病机制，其诊断具有挑战性，通常需要进行一系列多方面的评估，特别是对于血管免疫母细胞性T细胞淋巴瘤（三个亚类中最常见）。分子生物学领域的最新进展已解开T-FHCL的基因组景观，其发生的潜在机制，尤其是其独特的微环境发育，现在也得到了更好的理解。在该篇评论中，不仅总结了T-FHCL的病理特征、更新的诊断标准和分类，而且讨论了T-FHCL分子研究的最新进展及其在诊断和疾病分类中的应用。 |
| Key words: 滤泡辅助性T细胞淋巴瘤 血管免疫母细胞性T细胞淋巴瘤 滤泡T细胞淋巴瘤 具有滤泡辅助性T细胞表型的结内外周T细胞淋巴瘤 外周T细胞淋巴瘤 |
