摘要: |
[摘要] 肺癌是世界范围内发病率第一的恶性肿瘤,尽管其在治疗方面取得了进展,但其死亡率仍高居不下。究其根本,癌细胞的侵袭、转移是肺癌预后差及生存率低下的主要原因,其中癌细胞的侵袭和转移包括了上皮间充质转化、新生血管或淋巴管、癌细胞存活、外渗并在远端部位增生等阶段,其发生发展机制目前尚未清晰明了。现总结近年来有关肺癌侵袭、转移机制的研究进展以及现状并作一综述,以期为广大研究者提供参考。 |
关键词: 肺癌 侵袭 转移 |
DOI:10.3969/j.issn.1674-3806.2022.03.03 |
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Advances in studies on the invasion and metastasis mechanisms of lung cancer |
ZHANG Wen-qian, LI Hui
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Department of Thoracic Surgery, Affiliated Beijing Chaoyang Hospital of Capital Medical University, Beijing Institute of Respiratory Diseases, Beijing 100020, China
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Abstract: |
[Abstract] The incidence rate of lung cancer ranks first in the incidence rates of malignant tumours around the world, and despite its progress in treatment, its mortality rate remains high.Fundamentally, the invasion and metastasis of cancer cells are the main reasons for the poor prognosis and low survival rate of lung cancer. The invasion and metastasis of cancer cells include the following stages: epithelial-mesenchymal transition, neovascularization or lymphatics, cancer cell survival, extravasation and proliferation at the distal part. The occurrence and development mechanisms of these stages are not clear at present. This paper summarizes the advances in studies on the invasion and metastasis mechanisms of lung cancer in recent years and the current situation, and makes a review to provide reference for the majority of researchers. |
Key words: Lung cancer Invasion Metastasis |