| 摘要: |
| ［摘要］ 帕金森病（PD）是第二常见的神经退行性疾病，当前尚无有效的治疗方法，主要靠药物延缓疾病进展。PD是遗传、环境和衰老共同作用的结果，其发病机制复杂。其中神经炎症是PD发病机制的重要环节，近期研究报道以核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎症小体为核心的神经炎症在PD炎性机制中扮演重要角色，可能是PD的潜在治疗靶点。为此，该文将论述NLRP3炎症小体在PD中的活化方式及其可能的致病机制，并讨论以NLRP3炎症小体为靶点的PD治疗新方法，为深入认识NLRP3炎症小体在PD中的作用及发掘PD治疗新策略提供参考。 |
| 关键词: 帕金森病 核苷酸结合寡聚化结构域样受体蛋白3 炎症小体 神经炎症 |
| DOI：10.3969/j.issn.1674-3806.2022.12.05 |
| 分类号:R 741 |
| 基金项目:国家自然科学基金项目（编号：82260235）；广西自然科学基金项目（编号：2022GXNSFBA035511） |
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| New advances in therapy of Parkinson′s disease based on NLRP3 inflammasome |
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JIAO Xue, HUANG Shu-xuan
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Youjiang Medical University for Nationalities, Baise 533000, China; Department of Neurology, the People′s Hospital of Guangxi Zhuang Autonomous Region(Guangxi Academy of Medical Sciences), Nanning 530021, China
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| Abstract: |
| ［Abstract］ Parkinson′s disease(PD) is the second common neurodegenerative disease, for which there is no effective treatment currently. The treatment of PD mainly relies on drugs to delay the progression of the disease. PD is the result of genetics, environment and aging, and its pathogenesis is complex. Neuroinflammation is an important link to the pathogenesis of PD. Recent studies have reported that neuroinflammation induced by the activation of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3) inflammasome plays an important role in the pathogenic mechanism of PD, revealing that the inflammasome may be a potential therapeutic target for PD. Therefore, this paper discusses the activation mechanism as well as the possible pathogenic mechanism of NLRP3 inflammasome in PD, and probes new therapies of PD by targeting the NLRP3 inflammasome, so as to provide reference evidence for further understanding the exact role of NLRP3 inflammasome in PD and exploring new therapeutic strategies for PD treatment. |
| Key words: Parkinson′s disease Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3) Inflammasome Neuroinflammation |
