| 摘要: |
| ［摘要］ 目的 探讨利奈唑胺在ICU重症感染患者中应用的有效性及安全性。方法 对入住ICU的27例重症感染患者给予利奈唑胺0.6 g，2次/d，观察用药前和用药72 h后的体温、血常规、肝肾功能等指标的变化并进行对比分析，以评价药物的有效性及安全性。结果 27例患者中19例好转，8例死亡或自动出院，临床有效率为70.37%。使用利奈唑胺72 h后，患者体温血象均较前下降，血小板计数稍有下降，肝肾功能无明显变化，所观察的指标治疗前后差异无统计学意义（P>0.05）。结论 利奈唑胺在重症感染患者中短期应用是安全有效的，长期应用的药物副作用需要进一步观察。 |
| 关键词: 利奈唑胺 重症感染 药物安全性 |
| DOI：10.3969/j.issn.1674-3806.2015.06.07 |
| 分类号:R 978.1 |
| 基金项目:广西卫计委科研课题（编号：Z2013356） |
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| Analysis of linezolid in the treatment of 27 patients with severe sepsis in intensive care unit |
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XIANG Shu-lin, XIONG Bin
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Department of Critical Care Medicine, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To analyze the clinical efficacy and safety of linezolid in the treatment of severe sepsis in intensive care unit.Methods Twenty-seven patients with severe sepsis were treated with linezolid 0.6 gram twice per day and the blood routine examination, liver and renal function were tested before and 72 h after the medication to analyze the efficiency and safety of the treatment.Results The clinical efficacy rate was 70.37%, and there were no significant differences in the blood routine examination, liver and renal function before and after 72 hours′treatment of linezolid（P>0.05）.Conclusion Linezolid has conspicuous effectiveness and safety in the treatment of severe sepsis within 72 h in intensive care unit. |
| Key words: Linezolid Severe sepsis Drug safety |
