| 摘要: |
| ［摘要］ 目的 探讨不育男性司机精液质量及精子DNA完整率［精子DNA断裂指数（DFI）表示］与工作时间的关联性。方法 选取150例不育患者（职业司机110例，非职业司机且不开车患者40例），按每天开车时间分为3组：A组为每天开车1～5 h（50例）；B组为每天开车>5 h（60例）；C组为非职业司机且不开车即每天开车为0 h（40例），分析三组患者的精液质量及精子DNA完整率。结果 （1）C组患者精液量、精子活力PR、精子浓度及正常形态均高于A、B两组［（3.10±1.32）ml vs (2.16±0.88)ml、(1.27±0.72)ml;(39.01±9.01)% vs (27.38±6.00)%、(21.34±7.95)%;(25.80±17.92)106/ml vs (12.60±4.59)106/ml、(7.66±2.92)106/ml;(5.35±1.89)% vs (3.06±0.68)%、(2.10±0.82)%］，差异有统计学意义(P=0.000)。（2）A组患者精液量、精子活力PR及正常形态均高于B组［(2.16±0.88)ml vs (1.27±0.72)ml;(27.38±6.00)% vs (21.34±7.95)%;(3.06±0.68)% vs (2.10±0.82)%］，差异有统计学意义(P=0.000)。A组与B组精子浓度比较为［（12.60±4.59）106/ml vs (7.66±2.92)106/ml］，差异无统计学意义(P=0.090)。（3）B组患者DFI高于A组和C组［（21.54±12.28）% vs （13.00±8.29）%、（10.15±6.75）%］,差异有统计学意义（P=0.000）；A组与C组DFI比较差异无统计学意义［（13.00±8.29）% vs (10.15±6.75）%，P=0.172］。结论 男性司机的精液量、精子浓度、活力、正常形态、精子DNA完整率比非司机男性有下降趋势，男性司机的各项精子参数及精子DNA完整率随着每日开车时间的增加而下降。 |
| 关键词: 司机 男性不育 精液质量 精子DNA完整率 |
| DOI：10.3969/j.issn.1674-3806.2015.06.08 |
| 分类号:R 698+.2 |
| 基金项目:广西卫计委科研课题（编号：Z2014191；Z2011435）；广西医疗卫生适宜技术与开发课题（编号：S201421-03） |
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| The correlation between semen quality, sperm DNA integrity rate and working hours in infertility male drivers |
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HE Yong-zhi, LI Da-wen, HE Bing, et al.
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Guangxi University of Chinese Medicine, Nanning 530000,China
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| Abstract: |
| ［Abstract］ Objective To study the correlation between semen quality, sperm DNA integrity rate（DNA fragmentation index, DFI ） and working hours in infertility male drivers.Methods 150 infertility male patients(including 110 occupational drivers, 40 patients who never drove), were divided into 3 groups according to the driving hours every day: group A with driving 1～5 hours every day(n=50); Group B with driving >5 hours every day(n=60); Group C without driving every day(n=40).The semen quality and sperm DNA integrity rate were analyzed in the patients.Results (1)The quantity, vitality, concentration of sperms and PR in group C were higher than those in group A, B respectively［(3.10±1.32）ml vs (2.16±0.88)ml, (1.27±0.72)ml; (39.01±9.01)% vs (27.38±6.00)%, (21.34±7.95)%; (25.80±17.92)106/ml vs (12.60±4.59)106/ml, (7.66±2.92)106/ml; (5.35±1.89)% vs (3.06±0.68)%, (2.10±0.82)%］, P=0.000. (2)The motility and normal morphology of the sperms and PR in group A were higher than those in group B［(2.16±0.88)ml vs (1.27±0.72)ml; (27.38±6.00)% vs (21.34±7.95)%; (3.06±0.68)% vs (2.10±0.82)%］, P=0.000. There was no significant difference in the sperm concentration between the two groups［（12.60±4.59）106/ml vs (7.66±2.92)106/ml］. (3)DFI(%) of group B was higher than that of group A and group C［(21.54±12.28)% vs (13.00±8.29)%, (10.15±6.75)%］, P=0.000; DFI(%) was not significantly different between group A and group C［(13.00±8.29)% vs (10.15±6.75)%］, P=0.172.Conclusion Male drivers have poorer quality or quantity in sperm concentration, vitality, normal form and DNA integrity than the male controls who never drive and the longer time the male drivers drive, the poorer quality of the sperms they will have. |
| Key words: Driver Male infertility Semen quality Sperm DNA integrity rate |
