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肺转移性透明细胞肾细胞癌的临床病理学观察
张均林1，崔　峰2，韩思露3，王鑫怡3，林晓婷3，梅开勇3
1.罗定市人民医院病理科，广东 527200；2.桓台县中医院病理科，淄博 256400；3.广州医科大学附属第二医院病理科，广东 510260
摘要:
［摘要］　目的　探讨肺转移性透明细胞肾细胞癌临床病理学特点。方法　回顾性分析4例穿刺活检诊断肺转移性透明细胞肾细胞癌的临床病理特征，采用免疫组化染色检测CK、p40、p63、TTF-1、Napsin A、PAX8、CD10，观察其表达情况。结果　4例患者中，男3例，女1例，年龄44～71岁，平均58.75岁；均为双肺多发结节，其中各例最大的结节位于左下肺2例，右下肺2例。4例均表达CK、PAX8、CD10，而TTF-1、Napsin A、p40、p63阴性。结论　具有透明细胞形态特点的肺肿瘤需要考虑肺转移性透明细胞肾细胞癌的可能。
关键词:  肺  肾细胞癌  透明细胞  转移  病理
DOI：10.3969/j.issn.1674-3806.2024.07.07
分类号:R 730.2
基金项目:广州市科技计划项目（编号：201904010029）
Clinicopathological observation on clear cell renal cell carcinoma metastasizing to the lung
ZHANG Junlin1, CUI Feng2, HAN Silu3, WANG Xinyi3, LIN Xiaoting3, MEI Kaiyong3
1.Department of Pathology, Luoding People′s Hospital, Guangdong 527200, China; 2.Department of Pathology, Huantai TCM Hospital, Zibo 256400, China; 3.Department of Pathology, the Second Affiliated Hospital of Guangzhou Medical University, Guangdong 510260, China
Abstract:
［Abstract］　Objective　To explore the clinicopathological features of clear cell renal cell carcinoma metastasizing to the lung. Methods　The clinicopathological features of 4 cases of clear cell renal cell carcinoma metastasizing to the lung which was diagnosed by puncture biopsy were retrospectively analyzed. CK, p40, p63, TTF-1, Napsin A, PAX8 and CD10 were detected by using immunohistochemical staining method, and their expressions were observed. Results　Among the 4 patients with clear cell renal cell carcinoma metastasizing to the lung, there were 3 males and 1 female, aged 44-71 years, with an average age of 58.75 years. All the 4 cases had multiple nodules in both lungs, with the largest nodule of each case located in the left lower lobe of the lung in 2 cases and the right lower lobe of the lung in 2 cases. All the 4 cases were positive for CK, PAX8, and CD10 expressions, while negative for TTF-1, Napsin A, p40 and p63 expressions. Conclusion　Lung tumors characterized by clear cell morphology need to be considered for the possibility of clear cell renal cell carcinoma metastasizing to the lung.
Key words:  Lung  Renal cell carcinoma  Clear cell  Metastasis  Pathology