| 摘要: |
| ［摘要］ 目的 探讨华南地区结直肠癌组织中错配修复（MMR）蛋白的表达情况及临床病理特征。方法 收集广州达安临床检验中心2019年1月至2023年12月存档的结直肠癌病例3 188例，采用免疫组化法检测结直肠癌组织中MLH1、PMS2、MSH2、MSH6蛋白的表达情况，进一步分析其与临床病理特征的关系。结果 在3 188例结直肠癌中，发现错配修复蛋白缺失（MMRd）254例（缺失率为8.0%）；MLH1-/PMS2-共146例，占MMRd的57.5%；MSH2-/MSH6-共35例，占MMRd的13.8%。不同年龄、肿瘤部位及分化程度的MMRd发生率差异有统计学意义（P<0.05）。分析其中646例结直肠癌根治术样本，发现MMRd与肿瘤最大径、淋巴结转移、脉管侵犯、神经侵犯及癌结节密切相关（P<0.05）。结论 MMRd在华南地区结直肠癌中的发生率为8.0%，好发于年轻女性，肿瘤部位多见于回盲部及升结肠，以低分化为主。MMRd肿瘤常表现为肿瘤直径较大（≥5 cm）、淋巴结转移少见、癌结节少见、无脉管侵犯及无神经侵犯。 |
| 关键词: 结直肠癌 错配修复蛋白 微卫星不稳定 免疫组化 华南 |
| DOI：10.3969/j.issn.1674-3806.2024.07.08 |
| 分类号:R 735.3 |
| 基金项目: |
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| Expressions of mismatch repair proteins in 3 188 cases of colorectal cancer in south China area and their clinicopathological features |
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FU Qiaoyu, JIN Tian′en, JIANG Hanwen, HONG Juan, FANG Chutian, CHEN Zhongsheng
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Guangzhou Da′an Clinical Laboratory Center, Guangdong 510520, China
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| Abstract: |
| ［Abstract］ Objective To explore the expressions of mismatch repair(MMR) proteins in colorectal cancer tissues in south China area and their clinicopathological features. Methods A total of 3 188 cases of colorectal cancer archived at Guangzhou Da′an Clinical Laboratory Center from January 2019 to December 2023 were collected. Immunohistochemical method was used to detect the expressions of MLH1, PMS2, MSH2 and MSH6 proteins in colorectal cancer tissues, and the relationship between these protein expressions and clinicopathological features was further analyzed. Results Among the 3 188 cases of colorectal cancer, 254 cases(with a deficiency rate of 8.0%) were found to have mismatch repair protein deficiency(MMRd), and there were 146 cases of MLH1-/PMS2-, accounting for 57.5% of MMRd, and there were 35 cases of MSH2-/MSH6-, accounting for 13.8% of MMRd. There were significant differences in the incidence rates of MMRd between different ages, between tumor locations and between differentiation levels(P<0.05). Among the 3 188 cases of colorectal cancer, the analysis of specimens of 646 cases receiving radical resection for colorectal cancer revealed that MMRd was closely related to tumor maximum diameter, lymph node metastasis, vascular invasion, nerve invasion and cancer nodules(P<0.05). Conclusion The incidence rate of MMRd in colorectal cancer in south China area is 8.0%, and MMRd is more common in young women and their tumor sites are more common in ileocecum and ascending colon and these MMRd tumors are often poorly differentiated. MMRd tumors are often characterized by large tumor diameters(≥5 cm), rare lymph node metastasis, rare cancer nodules, no vascular invasion and no nerve invasion. |
| Key words: Colorectal cancer Mismatch repair protein Microsatellite instability Immunohistochemistry Southern China |
