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类风湿关节炎合并骨质疏松症分子信号通路机制的研究进展
王　欢1，王婷婷2，简聪聪3，杨　丽1，吴建红1，2
1.川北医学院临床医学院，四川 637000；2.达州市中心医院风湿免疫科，四川 635099；3.成都中医药大学基础医学院，四川 610072
摘要:
［摘要］　骨质疏松症（OP）是类风湿关节炎（RA）最常见的共病之一。RA合并OP会加重骨破坏，增加骨折风险，降低患者的生活质量，增加社会负担。其病因复杂，发病机制尚不完全清楚。RA合并OP的治疗是目前临床工作的难点。了解疾病的信号通路，可以为疾病诊疗提供新的手段。该文对RA合并OP分子信号通路机制的研究进展作一综述。
关键词:  类风湿关节炎  骨质疏松症  信号通路  发病机制
DOI：10.3969/j.issn.1674-3806.2024.09.22
分类号:R 593.22
基金项目:四川省医学会科技创新研究会科研项目（编号：YCH-ZZ2023-011）
Research progress on molecular mechanisms of the signaling pathways in rheumatoid arthritis complicated with osteoporosis
WANG Huan1, WANG Tingting2, JIAN Congcong3, YANG Li1, WU Jianhong1,2
1.School of Clinical Medicine, North Sichuan Medical College, Sichuan 637000,China; 2.Department of Rheumatology and Immunology, Dazhou Central Hospital, Sichuan 635099, China; 3.School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Sichuan 610072, China
Abstract:
［Abstract］　Osteoporosis(OP) is one of the most common comorbidities of rheumatoid arthritis(RA). RA complicated with OP can exacerbate bone destruction, increase the risk of fractures, reduce the patients′ quality of life and increase social burden. The etiology of RA complicated with OP is complex and its pathogenesis is not fully understood. At present, the treatment of RA complicated with OP is a difficult point in clinical work. Understanding the signaling pathways of the disease can provide a new means for developing diagnosis and treatment of the disease. In this paper, the research progress on molecular mechanisms of the signaling pathways in RA complicated with OP is reviewed.
Key words:  Rheumatoid arthritis(RA)  Osteoporosis(OP)  Signaling pathway  Pathogenesis