| 摘要: |
| ［摘要］ 近10多年来，经鼻高流量氧疗广泛应用于呼吸衰竭治疗。与传统氧疗相比，经鼻高流量氧疗能够维持吸入氧浓度稳定，不但提高血氧分压，还可以降低血二氧化碳分压、减少呼吸功和改善膈肌功能。临床研究证实，经鼻高流量氧疗治疗慢性阻塞性肺疾病急性呼吸衰竭优于传统氧疗，但是否非劣效于无创机械通气尚存在争议。需要更多大样本前瞻性随机对照研究优化经鼻高流量氧疗治疗慢性阻塞性肺疾病急性呼吸衰竭的方案和提供循证医学证据。 |
| 关键词: 慢性阻塞性肺疾病 呼吸衰竭 氧疗 经鼻高流量 |
| DOI：10.3969/j.issn.1674-3806.2025.02.05 |
| 分类号: |
| 基金项目:广西科学技术厅重点研发计划项目（编号：桂科AB16380218）；广西卫生健康委员会自筹经费科研课题（编号：Z20201027） |
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| High-flow nasal cannula oxygen therapy for acute respiratory failure in chronic obstructive pulmonary disease |
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QIN Zhiqiang, PAN Yanru
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Department of Respiratory Medicine, Foresea Life Insurance Guangxi Hospital, Nanning 530200, China
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| Abstract: |
| ［Abstract］ Over the past decade, high-flow nasal cannula(HFNC) oxygen therapy has been widely applied in treatment of respiratory failure.Compared with conventional oxygen therapy(COT), HFNC oxygen therapy can maintain stable fraction of inspired oxygen(FiO2), not only improve arterial oxygen partial pressure but also reduce arterial carbon dioxide partial pressure, decrease work of breathing, and improve diaphragmatic function. Clinical researches have confirmed that HFNC oxygen therapy is superior to COT in treating acute respiratory failure in chronic obstructive pulmonary disease(COPD). However, it remains controversial whether HFNC oxygen therapy is non-inferior to non-invasive ventilation(NIV). More large-scale, prospective, randomized controlled clinical trials are needed to optimize the treatment protocols and provide high-grade evidence-based medical support for HFNC oxygen therapy in treating acute respiratory failure in COPD. |
| Key words: Chronic obstructive pulmonary disease(COPD) Respiratory failure Oxygen therapy High-flow nasal cannula(HFNC) |
