| 摘要: |
| ［摘要］ 慢性阻塞性肺疾病（COPD）是常见的慢性气道疾病，患病率高，疾病负担重。随着宏基因检测技术的应用，发现肺部含有低生物量的菌群，肠道菌群和肺部菌群通过“肺-肠轴”存在潜在的联系，共同参与COPD的发展。与健康人群对比，COPD患者的肺部、肠道菌群组成和功能异常。基于COPD和肺部-肠道菌群的相互作用，通过干预肺部-肠道菌群防治COPD成为一个新的治疗方向。该文将概述COPD肺部-肠道菌群的分布特点，COPD和肺部-肠道菌群互相影响的作用机制研究进展，为COPD临床诊疗与研究提供新思路。 |
| 关键词: 慢性阻塞性肺疾病 肺部菌群 肠道菌群 肺-肠轴 |
| DOI：10.3969/j.issn.1674-3806.2025.02.04 |
| 分类号:R 563 |
| 基金项目:山西省科学技术厅青年科学研究项目（编号：202303021222368） |
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| Chronic obstructive pulmonary disease and gut-lung microbiota interactions: microbiome-based targeted treatment strategies |
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FENG Qiantong1, LI Aimin2
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1.Department of Respiratory and Critical Care Medicine, Shanxi Provincial Institute of TCM, the First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China; 2.Department of Respiratory and Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China
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| Abstract: |
| ［Abstract］ Chronic obstructive pulmonary disease(COPD) is a common chronic airway disease with high prevalence and heavy disease burden. With the application of metagenome detection technology, it has been found that the lungs contain low-biomass microbiota, and gut microbiota and lung microbiota have a potential connection through the “gut-lung axis”, and jointly participate in the development of COPD. Compared with healthy individuals, COPD patients have abnormal composition and function of lung microbiota and gut microbiota. Based on COPD and gut-lung microbiota interactions, the prevention and treatment of COPD by intervening the gut-lung microbiota have become a new therapeutic direction. In this paper, the distribution characteristics of gut-lung microbiota in COPD patients and the research progress of the mechanism of COPD and gut-lung microbiota interactions are summarized, providing new ideas for clinical diagnosis, treatment and research of COPD. |
| Key words: Chronic obstructive pulmonary disease(COPD) Lung microbiota Gut microbiota Gut-lung axis |
