| 摘要: |
| ［摘要］ 妇科恶性肿瘤不仅发病率较高，而且呈年轻化趋势，诊疗技术的快速发展明显延长了患者的生存期，且女性肿瘤幸存者绝经的中位年龄为44岁，明显早于正常女性的自然绝经年龄。值得重视的是，越来越多的女性正经历癌症治疗后所引起的早发性卵巢功能不全或早绝经导致的骨质疏松、心血管疾病和认知功能下降的风险，严重影响其生活质量。鉴于大部分有绝经症状的恶性肿瘤患者未能获得有效的治疗，该文将对妇科恶性肿瘤治疗后的激素补充治疗相关问题进行分析论述，为临床医师处理此类问题提供帮助。 |
| 关键词: 妇科恶性肿瘤 激素补充治疗 绝经 |
| DOI：10.3969/j.issn.1674-3806.2025.05.01 |
| 分类号:R 737.3 |
| 基金项目:国家自然科学基金项目（编号：82471672）；江苏省科技项目（编号：BK20241987）；江苏省医学重点学科/实验室（编号：ZDXK202210） |
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| Related issues of hormone replacement therapy after treatment of gynecologic malignant tumors |
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TAN Rongrong, WU Jie
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Department of Obstetrics and Gynecology, Jiangsu Province Hospital(the First Affiliated Hospital of Nanjing Medical University, Jiangsu Women and Children Health Hospital), Nanjing 210029, China
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| Abstract: |
| ［Abstract］ The incidence of gynecologic malignant tumors is not only relatively high but also shows a trend of younger age. The rapid development of diagnosis and treatment techniques has significantly prolonged the survival period of the gynecologic malignant tumor patients, and the median age of the survivors of gynecologic malignant tumor patients at menopause is 44 years, which is significantly earlier than that of normal females at natural menopause. It is worth noting that more and more women are experiencing the risk of premature ovarian insufficiency or osteoporosis, cardiovascular diseases and cognitive decline caused by early menopause after cancer treatment, which seriously affect their quality of life. Given that the majority of cancer patients with menopausal symptoms have not received effective treatment, this paper analyzes and discusses the issues related to hormone replacement therapy after treatment of gynecologic cancer, providing assistance for clinicians in dealing with such problems. |
| Key words: Gynecologic malignant tumors Hormone replacement therapy Menopause |
