| 摘要: |
| ［摘要］ 目的 观察雌激素联合壮医针刺疗法治疗薄型子宫内膜对冻融胚胎移植助孕效果的影响。方法 招募2022年3月至2024年6月广西壮族自治区人民医院生殖医学与遗传中心接受冻融胚胎移植助孕的薄型子宫内膜患者137例，采用随机数字表法将其分为对照组（采用常规雌激素治疗方案准备内膜，69例）和观察组（在常规雌激素治疗方案的基础上增加壮医针刺疗法，68例）。在治疗过程中，对照组剔除9例，观察组剔除8例，最终两组各有60例纳入分析。比较两组子宫内膜厚度、子宫内膜血流分级、血清雌二醇（E2）和孕酮（P）水平以及妊娠结局。记录不良反应的发生情况。结果 观察组治疗后子宫内膜较对照组更厚，差异有统计学意义（P<0.05）。观察组治疗后子宫内膜血流分级情况显著优于对照组（P<0.05）。两组治疗前后血清E2、P水平比较差异无统计学意义（P>0.05）。观察组着床率、临床妊娠率高于对照组，差异有统计学意义（P<0.05）。所有患者在治疗期间均未出现严重不良反应。结论 雌激素联合壮医针刺疗法可有效改善子宫内膜厚度，提高临床妊娠率。 |
| 关键词: 雌激素 壮医针刺疗法 薄型子宫内膜 冻融胚胎移植 妊娠 |
| DOI：10.3969/j.issn.1674-3806.2025.07.13 |
| 分类号:R 711.74 |
| 基金项目:广西自然科学基金项目（编号：2024GXNSFBA010064）；广西中医药管理局科研课题项目（编号：GXZYZ20210115，GXZYA20220186）；广西卫生健康委员会科研课题项目（编号：Z20210984）；广西中医药适宜技术开发与推广项目（编号：GZSY22-55） |
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| Effect of estrogen combined with Zhuang acupuncture therapy in treatment of thin endometrium on frozen-thawed embryo transfer for assisted pregnancy |
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CHI Yan1, LIU Liling1, QIN Jie1, HUANG Taishuai1, HE Zhou2
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1.Center for Reproductive Medicine and Genetics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China; 2.Department of Acupuncture and Moxibustion, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe the effect of estrogen combined with Zhuang acupuncture therapy in treatment of thin endometrium on frozen-thawed embryo transfer for assisted pregnancy. Methods A total of 137 patients with thin endometrium who received frozen-thawed embryo transfer for assisted pregnancy in Center for Reproductive Medicine and Genetics, the People′s Hospital of Guangxi Zhuang Autonomous Region from March 2022 to June 2024 were recruited. The patients were divided into control group(receiving conventional estrogen treatment regimen for preparing the endometrium, 69 patients) and observation group(receiving conventional estrogen treatment regimen plus Zhuang acupuncture therapy for preparing the endometrium, 68 patients). During the treatment process, 9 patients were excluded from the control group and 8 patients from the observation group. Eventually, 60 patients were included in each group for the analysis. The endometrial thickness, the grade of endometrial blood flow, serum estradiol(E2) and progesterone(P) levels, and pregnancy outcomes were compared between the two groups. The occurrence of adverse reactions was recorded. Results After the treatment, the endometrium in the observation group was thicker than that in the control group, and the difference was statistically significant(P<0.05). After the treatment, the endometrial blood flow grade in the observation group was significantly better than that in the control group(P<0.05). There were no statistically significant differences in the levels of serum E2 and P between the two groups before and after the treatment(P>0.05). The implantation rate and clinical pregnancy rate in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). No serious adverse reactions occurred in all the patients during the treatment period. Conclusion Estrogen combined with Zhuang acupuncture therapy can effectively improve endometrial thickness and increase clinical pregnancy rate. |
| Key words: Estrogen Zhuang acupuncture therapy Thin endometrium Frozen-thawed embryo transfer Pregnancy |
