| 摘要: |
| ［摘要］ CO外固定技术是基于中国接骨学的发展创新，在四肢骨折的治疗中具有良好的临床疗效，符合骨折愈合的生物力学原理。然而，CO外固定技术促进骨折愈合的分子生物学机制尚不明确。该文从CO外固定技术的中医理论基础、生物力学原理出发，探讨其促进骨髓间充质干细胞成骨分化、内皮祖细胞血管化方面的分子生物学机制，并总结可能参与其中的信号通路，这将为骨折的中医治疗科学化及CO外固定技术的实验研究提供新的思路。 |
| 关键词: 中国接骨学 CO外固定 生物力学 骨折愈合 |
| DOI：10.3969/j.issn.1674-3806.2025.10.22 |
| 分类号:R 274.1 |
| 基金项目:中国中医科学院望京医院高水平中医医院建设项目（编号：WJYY-XZKT-2023-14）；北京市科技计划课题（编号：Z221100007422075）；河南省中医药科学研究专项课题（编号：2024ZY2197）；中国中医药信息学会科研项目（编号：CACMS-KY-2023008） |
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| Discussion on mechanisms of CO external fixation technique of traditional Chinese orthopedics in promoting fracture healing |
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LIU Fei1, LI Xiaomin1, LI Rui1, DAI Junze1, CHENG Yongzhong1, WANG Chaolu1,2
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1.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China; 2.Nanyang Chinese Medicine Hospital, Nanyang 473000, China
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| Abstract: |
| ［Abstract］ CO external fixation technique, an innovation based on the development of traditional Chinese orthopedics, demonstrates good clinical efficacy in treatment of limb fractures and aligns with the biomechanical principles of fracture healing. However, the molecular biological mechanisms by which CO external fixation technique promotes fracture healing remain unclear. This paper discusses the molecular biological mechanisms of CO external fixation technique in promoting osteogenic differentiation of bone marrow mesenchymal stem cells and vascularization of endothelial progenitor cells on the basis of traditional Chinese medicine theory and biomechanical principles of CO external fixation technique, and summarizes the signal pathways that may be involved in these molecular biological mechanisms, which will provide new ideas for the scientific treatment of fractures in traditional Chinese medicine and the experimental researches of CO external fixation technique. |
| Key words: Traditional Chinese orthopedics CO external fixation Biomechanics Fracture healing |
