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多发性肌炎的复杂免疫病理机制与多靶点治疗的研究进展
马靖淑1，高孟珣1，户毛毛1，王苗苗1，马飞兰1，郭东更1，2，3
1.宁夏回族自治区人民医院（宁夏医科大学第三临床医学院），银川 750002；2.宁夏自身免疫性疾病精准医学重点实验室，银川 750002；3.宁夏回族自治区人民医院风湿免疫科，银川 750002
摘要:
［摘要］　多发性肌炎是一种罕见自身免疫性异质性疾病，以对称性近端肌无力为主要临床表现，可影响患者的生活质量和预期寿命。其病因及发病机制复杂且具有较强的异质性，涉及遗传易感性因素、环境诱发因素以及免疫系统等多个层次和通路。该文对多发性肌炎的复杂免疫病理机制与多靶点治疗的研究进展作一综述。
关键词:  多发性肌炎  免疫病理机制  多靶点治疗  肌炎特异性抗体
DOI：10.3969/j.issn.1674-3806.2025.12.17
分类号:R 593.26
基金项目:国家自然科学基金项目（编号：81760299）；宁夏回族自治区重点研发（重大）项目（编号：2024BEG01003）；宁夏回族自治区科技领军人才项目（编号：2024GKLRLX09）
Research progress in complex immunopathogenesis and multi-target therapy of polymyositis
MA Jingshu1, GAO Mengxun1, HU Maomao1, WANG Miaomiao1, MA Feilan1, GUO Donggeng1,2,3
1.People′s Hospital of Ningxia Hui Autonomous Region(Third School of Clinical Medicine, Ningxia Medical University), Yinchuan 750002, China; 2.Ningxia Key Laboratory of Precision Medicine for Autoimmune Diseases,Yinchuan 750002, China; 3.Department of Rheumatology and Immunology, People′s Hospital of Ningxia Hui Autonomous Region, Yinchuan 750002, China
Abstract:
［Abstract］　Polymyositis(PM) is a rare heterogeneous autoimmune disorder, characterized by symmetrical proximal muscle weakness as the mainly clinical manifestation, which can affect the quality of life and life expectancy of the patients. The etiology and pathogenesis of PM are complex and highly heterogeneous, involving multiple levels and pathways such as genetic susceptibility, environmental triggering factors and the immune system. In this paper, the research progress in complex immunopathogenesis and multi-target therapy of PM is reviewed.
Key words:  Polymyositis(PM)  Immunopathogenesis  Multi-target therapy  Myositis-specific autoantibodies(MSAs)