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腹腔热灌注化疗联合多模式治疗调控妇科恶性肿瘤微环境的研究进展
段仕倩1，杨　将2，文诗雨1，覃小敏2
1.武汉科技大学医学部医学院，武汉 430000；2.湖北文理学院附属襄阳市中心医院妇产科，湖北省子宫颈病变临床医学研究中心，襄阳 441100
摘要:
［摘要］　宫颈癌、子宫内膜癌及卵巢癌的全球疾病负担持续加重，且发病年龄呈现年轻化趋势。作为新兴治疗策略，腹腔热灌注化疗（HIPEC）通过构建热-化疗协同作用体系，已证实可显著改善晚期、复发或转移性妇科恶性肿瘤患者的预后，尤其体现在经间歇性肿瘤细胞减灭术治疗后的卵巢癌患者中。鉴于肿瘤微环境的调控是HIPEC发挥疗效的关键机制，深入研究该机制有望为患者提供更为精准的个体化治疗方案。该文对HIPEC联合多模式治疗调控妇科恶性肿瘤微环境的研究进展作一综述。
关键词:  妇科恶性肿瘤  腹腔热灌注化疗  肿瘤微环境  精准治疗  联合治疗
DOI：10.3969/j.issn.1674-3806.2025.12.18
分类号:R 737.3
基金项目:湖北省自然科学基金计划项目（编号：2024AFD428）
Research progress of hyperthermic intraperitoneal chemotherapy combined with multimodal therapy in regulating the microenvironment of gynecological malignant tumors
DUAN Shiqian1, YANG Jiang2, WEN Shiyu1, QIN Xiaomin2
1.School of Medicine, Department of Medicine, Wuhan University of Science and Technology, Wuhan 430000, China; 2.Department of Obstetrics and Gynecology, Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science, Hubei Provincial Clinical Medical Research Center for Cervical Lesions, Xiangyang 441100, China
Abstract:
［Abstract］　The global burden of diseases in cervical cancer, endometrial cancer and ovarian cancer continues to increase, and the onset age of patients with these diseases shows a trend of getting younger. As an emerging therapeutic strategy, hyperthermic intraperitoneal chemotherapy(HIPEC) has been proven to significantly improve the prognosis of patients with advanced, recurrent or metastatic gynecological malignant tumors by constructing a synergistic thermochemotherapy system, especially in ovarian cancer patients after interval cytoreductive surgery. Given that the regulation of tumor microenvironment is a key mechanism for HIPEC to exert therapeutic effects, in-depth research on the mechanism is expected to provide the patients with more precise personalized treatment regimens. In this paper, the research progress of HIPEC combined with multimodal therapy in regulating the microenvironment of gynecological malignant tumors is reviewed.
Key words:  Gynecological malignant tumors  Hyperthermic intraperitoneal chemotherapy(HIPEC)  Tumor microenvironment  Precision treatment  Combined treatment