| 摘要: |
| ［摘要］ 代谢性疾病发病率呈上升趋势，严重影响人们的身体健康。脂肪组织表型转化是调控代谢性疾病的关键靶点，促进脂肪褐变，可显著改善胰岛素抵抗和能量失衡，而脂肪组织白色化会加剧炎症反应，加速疾病进展。该文对脂肪组织表型转化机制及对代谢性疾病作用的研究进展作一综述。 |
| 关键词: 棕色脂肪组织 白色脂肪组织 米色脂肪组织 脂肪组织表型转化 代谢性疾病 |
| DOI：10.3969/j.issn.1674-3806.2026.01.18 |
| 分类号:R 589 |
| 基金项目:山东省自然科学基金项目（编号：ZR2024MH344） |
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| Research progress in mechanism of adipose tissue phenotype transformation and its role in metabolic diseases |
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WEI Xiaomei1, DING Yabin1, XIANG Xinxin2
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1.School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China; 2.Center for Translational Medicine, Zibo Central Hospital, Zibo 255036, China
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| Abstract: |
| ［Abstract］ The incidence of metabolic diseases is on the rise, seriously affecting people′s physical health. Adipose tissue phenotype transformation is a key target for regulating metabolic diseases, promoting adipose tissue browning, significantly improving insulin resistance and energy imbalance, while adipose tissue whitening exacerbates inflammatory responses and accelerates disease progression. In this paper, the research progress in the mechanism of adipose tissue phenotype transformation and its role in metabolic diseases is reviewed. |
| Key words: Brown adipose tissue White adipose tissue Beige adipose tissue Adipose tissue phenotype transformation Metabolic diseases |
