| 摘要: |
| ［摘要］ 目的 探讨控释地诺前列酮栓在促宫颈成熟中的临床效果。方法 采用随机对照研究的方法，以无阴道分娩禁忌、足月妊娠、宫颈Bishop评分≤6分的初产妇160例为观察对象，采取自愿的原则，观察组60例采用阴道内放置控释地诺前列酮栓，对照组100例采用静脉滴注小剂量缩宫素，对比两组孕妇引产成功率及分娩结局。结果 观察组置药后临产率、24 h阴道分娩率分别为98.33%、76.66%，明显高于对照组85.00%、10.00%（P均<0.05）；剖宫产、产后出血、软产道裂伤、新生儿窒息率两组比较差异无统计学意义（P>0.05），宫缩过频过强为地诺前列酮栓的主要不良反应，研究组发生2例，但是取出该药后好转。结论 控释地诺前列酮栓促宫颈成熟效果明显优于缩宫素，它是一种有效、方便、安全的促宫颈成熟和引产的药物，对母子无不良影响。 |
| 关键词: 控释地诺前列酮栓 足月妊娠 促宫颈成熟 引产 |
| DOI：10.3969/j.issn.1674-3806.2011.08.16 |
| 分类号:R 719.3+1 |
| 基金项目: |
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| Clinical study of efficacy and safety of controlled-release dinoprostone suppository used in full-term pregnancy for cervical ripening and induced delivery |
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ZHANG Dong-mei, LIN Hong, ZHOU Ni
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Department of Gynecology and Obstetrics,Nanning Women and Child Health Hospital,Guangxi 530012,China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical effects of controlled-release dinoprostone suppository in cervical ripening. Methods A randomized control study was performed in 160 primiparas of vaginal delivery without taboo, full-term pregnancy, cervical Bishop score of 6 or less. Experimental group (n=60) received controlled-release dinoprostone suppository, while control group (n=100) received intravenous drip of low dose oxytocin voluntarily. Then artificial labor success rate with vaginal delivery were compared. Results After administration, production rate, 24 h vaginal delivery parturition rate in the experimental group were 98. 33% and 76. 66% respectively, and those in the control group were 85. 00%, 10. 00%, there was significant difference between the experimental group and control group(P<0. 05), while no significant differences were found in caesarean birth, postpartum hemorrhage, injuries of the soft birth canal, Neonatal asphyxia rate between the two groups（P>0. 05）. The chief side effect of controlled-released dinoprostone was titanic contraction of uterine. Two cases in experimental group had the chief side effect, and recovered after discontinuation. Conclusion Controlled-release dinoprostone suppository is more effective, convenient and safe than oxytoncin for cervical ripening and induced delivery, and no adverse effects on mother and child. |
| Key words: Controlled-release dinoprostone suppository Full-term pregnancy Cervical ripening Induced delivery |
