| 摘要: |
| ［摘要］ 目的 探讨癌基因E6/E7 mRNA定量检测联合液基薄层细胞学检测（TCT）在宫颈病变患者中的应用价值。方法 回顾性收集2010-05～2014-06我院收治的647例宫颈病变患者，采用宫颈病变患者癌基因E6/E7 mRNA定量检测联合TCT与临床病理检测的结果进行统计分析。结果 E6/E7 mRNA定量随TCT检测中不典型鳞状上皮细胞（ASCUS）、低度鳞状上皮细胞病变（LSIL）、高度鳞状上皮病变（HSIL）、宫颈癌及随病理分型中炎症反应、CIN Ⅰ级、CIN Ⅱ级、CIN Ⅲ级及宫颈癌呈逐渐递增趋势，且各组之间的差异均有统计学意义（P<0.05）。结论 癌基因E6/E7 mRNA定量检测联合TCT可作为宫颈病变患者分级及宫颈癌早期筛查的手段。 |
| 关键词: 宫颈病变 E6/E7 mRNA 液基薄层细胞学检测 病理组织学检测 |
| DOI：10.3969/j.issn.1674-3806.2016.10.05 |
| 分类号:R 737 |
| 基金项目:广西卫计委科研课题（编号：Z2014345） |
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| The value of quantitative detection of cancer gene E6/E7 mRNA combined with thinprep cytology test in the patients with cervical lesions |
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PAN Qi-wen, LI Jian-xiang, BAN Ting
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The People′s Hospital of Hechi City, Guangxi 547000, China
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| Abstract: |
| ［Abstract］ Objective To explore the value of quantitative defection of cancer gene E6/E7 mRNA combined with thinprep cytology test(TCT) in the patients with cervical lesions.Methods The data of 647 patients with cervical lesions in our hospital from May 2010 to June 2014 were retrospectively analyzed. Their cancer genes E6/E7 mRNA were quantitatively detected and these results combined with the results of TCT detection and the clinical pathological tests were compare between them.Results ASCUS,LSIL, NSIL, and cervical cancer by quantitative detection of E6/E7 mRNA combined with TCT detection, went along with the severity levels of pathological classification from inflammation, CINⅠ,Ⅱ to CINⅢ, with significant differences among the groups(P<0.05).Conclusion Quantitative detection of Oncogene E6/E7 mRNA combined with TCT may be used as for classifying cervical lesions of cervical cancer and early screening. |
| Key words: Cervical lesions E6/E7 mRNA Thinprep cytology test(TCT) Pathological examination |
